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from

necessity

to

innovation

Trasformative Bioskin Products
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Advanced Research In The Biology Of The Skin
Clinically Tested

Discover the power of our
Caviar-Based Skincare Product Range

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The fusion of science, nature, and an instinctive allure of 

Italian beauty come to life in 

our  

skincare creations.

for everyone, for all skin
Expert Skincare Tips Tailored Just For You
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ABOUT

LE SISS" is more than just a skincare brand: it is a testament to the power of family bonds, a shared passion, and a commitment to making a positive impact in the world of skincare.

​Their commitment to understanding the science of skincare and the interactions of different ingredients showcases their dedication to creating products that deliver the best possible outcomes. 

The Art Of Science

Behind the scenes, a team of dedicated chemical scientists works tiredless to deliver the highest quality skincare. The products undergo rigorous testing and formuation to ensure their effectivness and safety.  

At "LE SISS", 97% of the ingridients are sourced from nature, offering the goodness of natural elements with every application.  

We belive that nature provide the foundation for healthy skin. 

Finding Inspiration In Every Turn 
Aida Hoxha
Co-founder &
Medical Aesthetic Practitioner 
Rovena Hoxha
Co-founder &
Scientific Director / Formulater
 
Brunilda Hoxha
Co-founder &
International Public Relationship
WHAT SETS "LE SISS" APART

At LE SISS, we create more than just skincare; we craft a personalized luxury experience that blends nature, science, and artistry. Here’s what makes us stand out:

Unparalleled Concentrations of Active Ingredients
Our products feature 10% to 20% concentrations of caviar extract and hyaluronic acid—far exceeding the norms of even the most prestigious skincare brands. This ensures extraordinary efficacy and visible, transformative results.

97%+ Natural Ingredients
Every product in our collection is crafted with over 97% natural ingredients, combining the purity of nature with the power of cutting-edge science for formulations that are both gentle and effective.

Crafted with Care, Just for You

Developed by our co-founder and produced in a small, state-of-the-art laboratory, our skincare is almost artisanal, ensuring meticulous quality and care. Every product is crafted as if it were made just for you, delivered directly from our laboratory to your home.

Science Meets Beauty

Rooted in a profound understanding of skin biology, we merge the best of natural ingredients with advanced scientific research to create skincare that works in harmony with your skin while offering a truly luxurious experience.

Expertise You Can Trust
With over 25 years of combined expertise in medicine, pharmaceuticals, and cosmetics, our team ensures every formula reflects a dedication to excellence, precision, and the art of skincare.

Italian Elegance, Redefined

Inspired by the timeless allure of Italian beauty, our products bring a touch of refinement to your daily rituals, making every moment feel indulgent and sophisticated.

Sustainability at Heart
From sustainably sourced ingredients to eco-friendly packaging, we are committed to protecting the planet while delivering products that nurture your skin.

Luxury That Delivers
With higher concentrations of active ingredients, 97%+ natural formulations, and a handcrafted approach, our products go beyond luxury—they deliver results, indulgence, and a connection to nature and innovation.

At LE SISS, we combine passion, expertise, and the elegance of Italian beauty to create skincare that is as unique as you are. Because you deserve nothing but the best.

Contact Us
‘Love of beauty is taste.
The creation of beauty is art.’

R.W. Emerson

          + 44 (0) 77 03 77 88 54.                  

          info@opiderma.com

© 2025 Opiderma

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